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Effect of Patient Self-testing and Self-management of Long-Term Anticoagulation on Major Clinical Outcomes

Annals of Internal Medicine 2011;154:472-482.

Hanna E. Bloomfield, MD, MPH; Ange Krause, MD; Nancy Greer, PhD; Brent C. Taylor, PhD, MPH; Roderick MacDonald, MS;

Indulis Rutks, BS; Preetham Reddy, MD; and Timothy J. Wilt, MD, MPH

 

Background: Anticoagulation with vitamin K antagonists reduces major thromboembolic complications in at-risk patients. With portable monitoring devices, patients can conduct their own international normalized ratio testing and dose adjustment at home.

Purpose: To determine whether patient self-testing (PST), alone or in combination with self-adjustment of doses (patient self management [PSM]), is associated with a reduction in thromboembolic complications and all-cause mortality without an increase in major bleeding events compared with usual care.

 

Conclusion: Compared with usual care, PST with or without PSM is associated with significantly fewer deaths and thromboembolic events, without increased risk for a serious bleeding event, for a highly selected group of motivated adult patients requiring long-term anticoagulation with vitamin K antagonists.

 

 

 

 

 

 

 

 

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